Direct lipolytic effects related to the mechanical action of the flow of gas injected into the hypodermis without damage to other tissues and an indirect lipolytic effect related to the ability of the gas to increase the bioavailability of O2 (enhancement of the Bohr effect) for adipocyte metabolic activities, including oxidative processes of fatty acids.
A further “fat-burning” effect is due to the mechanical activation of specific skin receptors (Golgi and Pacini corpuscles) and the release of molecules (bradykinin, serotonin, AMPc…) that activate, through complex biomolecular mechanisms, several enzymatic systems including intralipocyte lipases, thus obtaining the hydrolysis of triglycerides (1 glycerol + 3 fatty acids).